antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
نویسندگان
چکیده
dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. in this study, antihypertensive effects of 5 newly synthesized derivatives of dhp was examined the in rat model of two-kidney, one-clip renal hypertension. the results showed that those compounds containing two nitroxy groups had less decreasing effect on map (men arterial pressure) compared to those having one nitroxy group in 5 position. on the other hand, conformational analysis indicated that in two compounds with two chains (a and e), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors.
منابع مشابه
Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of two-kidney, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial...
متن کاملAntihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of two-kidney, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial...
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Baroreflex function was studied in conscious early phase (<6 weeks) two-kidney, one-clip hypertensive rats before and 24 hours after surgical reversal of hypertension by removal of the constricting renal artery clip or after pharmacological reduction of blood pressure by an infusion of hydralazine or captopril. A normotensive sham-clipped group was included. Another group of two-kidney, one-cli...
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It has been suggested that in two-kidney, one clip hypertension, the undamped kidney (UK) actively contributes to hypertension by reducing its excretory ability in response to increased levels of Circulating angiotensin II. By exteriorizing the ureter to the dog's flank several weeks beforehand, we measured renal function directly from the UK of six chrogic renal hypertensive (> 3 weeks) and si...
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Attempted correction of two-kidney, one clip Goldblatt hypertension in the rat was carried out by three techniques; removal of the constricting clip, removal of the ischemic kidney, and converting enzyme blockade by oral captopril. Since duration of hypertension is said to be a critical factor, groups of rats were studied after short term (less than 6 weeks from clipping) and chronic (greater t...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۲۰۰۹، شماره ۷، صفحات ۱۹۳-۱۹۹
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